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KMID : 1155220160410030318
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Journal of the Korean Society of Health Information and Health Statistics
2016 Volume.41 No. 3 p.318 ~ p.323
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Dose-response Relationship between Serum Metabolomics and the Risk of Stroke
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Jee Yon-Ho
Jung Keum-Ji
Lim Youn-Hee
Lee Ye-Seung
Park Young-Ja
Jee Sun-Ha
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Abstract
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Objectives: Except the known risk factors for stroke, few studies have identified novel metabolic markers that could effectively detect stroke at an early stage. In this study, we explored the dose-response relationship between serum metabolites and the incidence of stroke.
Methods: We studied 213 adults in the Korean Cancer Prevention Study-II (KCPS-II) biobank and estimated dose-response relationship between serum metabolites and stroke (42 cases and 171 controls). Three serum metabolites (Acetylcholine, HexadecylAcetylGlycerol, and 1-acetyl-2-formyl-sn-glycero-3-phosphocholine) were used in this study. The analysis included (1) exploratory nonlinear analysis, (2) estimation of flexion points and slopes at below and above the points. In the model to estimate risk of incidence of stroke, we controlled for conventional risk factors such as age, sex, systolic blood pressure, type 2 diabetes, tri-glyceride, and smoking status.
Results: The relationship between incidence of stroke and log-transformed 1-acetyl-2-formyl-sn-glycero-3-phosphocho-line was non-linear with flexion point around intensity score of 8.8, whereas other metabolites, log-transformed Acetylcholine and HexadecylAcetylGlyc-erol, showed negative linear patterns.
Conclusions: The study suggests that metabolic markers are associated with incidence of stroke, particularly, at or above the flexion point. The study result may contribute to developing a novel system for precise stroke prediction.
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KEYWORD
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Cohort study, Dose-response, Metabolites, Stroke
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